Title list by research areas [Osaka University Biomedical R&D Seeds 2023]

• Drugs (Cancer)
• Drugs (Brain and Psychiatry)
• Drugs (Intractable diseases)
• Drugs (Cardiovascular diseases)
• Drugs (Infectious diseases)
• Drugs (Others)
• Medical devices
• Regenerative medicine
• Diagnostics

Drugs (Cancer)

• Development of synthetic vaccines against pancreatic cancer (Graduate School of Sciense, Professor Koichi FUKASE)
• Development of light-harvesting photosensitizers for deep-tissue photodynamic therapy (Department of Applied Chemistry, Graduate School of Engineering, Associate Professor (Lecturer) Hajime SHIGEMITSU)
• Development of the new anti-cancer medicine targeting GREB1, a novel Wnt signal-related molecule (Center for Infectious Disease Education and Research, Specially Appointed Professor Akira KIKUCHI, Department of Molecular Biology & Biochemistry, Graduate School of Medicine, Associate Professor Shinji MATSUMOTO)
• Research and development of intellectual property for epigenomic drug discovery that dually targets cancer stem cells and cancer immunity (Department of Medical Data Science, Graduate School of Medicine, Professor Hideshi ISHII)
• Maximizing cost-effectiveness by conjugating modifications for clinical application of innovative nucleic acid drugs (Department of Medical Data Science, Graduate School of Medicine, Professor Hideshi ISHII)
• Development of novel therapeutic agents for refractory BRAF mutation-positive colorectal cancer (Department of Gastroenterological Surgery, Graduate School of Medicine, Faculty of Medicine Lecturer Hidekazu TAKAHASHI)
• Development of anti-cancer drug targetting CKAP4 (Center for Infectious Disease Education and Research, Specially Appointed Professor Akira KIKUCHI)
• Development of antisense oligonucleotide medicine for the treatment of neuroendocrine cancer (Graduate School of Pharmaceutical Sciences, Specially Appointed Associate Professor Masahito SHIMOJO)
• Rapid clinical application of specific inhibitors targeting refractory gastrointestinal cancer stem cells (Department of Medical Data Science, Graduate School of Medicine, Professor Hideshi ISHII)
• Development of Nucleic Acid Lipid Nanoparticles with Anticancer Effects (Department of Cellular Immunology, Research Institute for Microbial Diseases, Associate Professor Taiki AOSHI)
• Innovative alpha therapy targeting PSMA for refractory prostate cancer (Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Assistant Professor Tadashi WATABE)
• Verification of the antitumor effect of aromatic amine derivatives and acquisition of preclinical POC (Department of Bio-system Pharmacology, Graduate School of Medicine, Professor Yoshikatsu KANAI)
• Targeted alpha-ray therapy for refractory thyroid cancer (Department of Nuclear Medicine and Tracer Kinetics, Graduate School of Medicine, Assistant Professor Tadashi WATABE)

Drugs (Brain and Psychiatry)

• Development of therapeutic agents for amyotrophic lateral sclerosis by improving ribosome function (Department of Neurotherapeutics, Graduate School of Medicine, Professor Seiichi NAGANO)
• Development of ASOs for multiple system atrophy (Department of Neurology, Graduate school of Medicine, Professor Hideki MOCHIZUKI)

Drugs (Intractable diseases)

• region-specific LOH-inducing applied to HLA region and the sensitive region extracted by GWAS (Genome Editing Research and Development Center, Graduate School of Medicine, Assistant professor Yasuhide YOSHIMURA)
• Development of inhibitors of protein phosphatases involved in neurodegenerative diseases and investigation of their effects in animal models (The department of Biological Control, RIMD, Specially Appointed Assistant Professor Shizuka ISHITANI)

Drugs (Cardiovascular diseases)

• Development for ex vivo diagnostic equipment for triglyceride deposit cardiomyovasculopathy (Triglyceride Science, Graduate School of Medicine, Specially Appointed Professor Ken-ichi HIRANO)
• Novel therapeutic strategy for cerebral stroke using Npas4-related factors (Graduate School of Medicine, Professor Taiichi KATAYAMA; Graduate School of Frontier Bioscience, Guest Professor Akio TSUBOI)
• Development of First-in-class Drug for Bradyarrhythmia (NTC-801F KACh Channel Inhibitor Phase II clinical trial) (Department of Cardiovascular Medicine, Graduate School of Medicine, Specially Appointed Associate Professor Yoshihiro ASANO)

Drugs (Infectious diseases)

• Development of Reoviridae virus-based mucosal vaccine vector systems (Research Institute for Microbial Diseases, Professor Takeshi KOBAYASHI)
• Enhancer Compounds of Gene Transfer by controlling the Autophag y mechanism (Graduate School of Frontier Biosciences, Guest Professor Hidesato OGAWA)
• Development of therapeutic strategy for mosquito-borne diseases by targeting mosquito saliva (Research Institute for Microbial Diseases/Institute for Advanced Co-Creation Studies, Assistant Professor Tatsuya SUZUKI)
• Development of Anti-Adhesive Agents against Enteric Infectious Diseases (Research Institute for Microbial Diseases, Specially Appointed Associate Professor Shota NAKAMURA)
• Clinical Development of NPC-BKSE36/CpG Malaria Vaccine (Department of Malaria Vaccine Development, Research Institute for Microbial Diseases, Endowed Chair Professor Toshihiro HORII)

Drugs (Others)

• Development of single-molecule imaging-based screening technology for drug discovery (Graduate School of Frontier Biosciences, Professor Masahiro UEDA)
• Development of repair therapy for skin barrier function by product lipids of novel lipase (Department of Bio-system Pharmacology, Graduate School of medicine, Associate Professor Ryuichi OHGAKI)
• Establishment of a new strategy for the treatment of functional restoration in skeletal muscle injury by tissue engineering using osteopontinederived SVVYGLR peptide (1st Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Professor Susumu TANAKA)
• A new anti-inflammatory drug that utilizes the active site of an endogenous NFκB direct inhibitory protein (Department of Obstetrics & Gynecology, Graduate School of Medicine, Guest Associate Professor Kazuki OKAMOTO)

Medical devices

• Development of a new disinfection device using Pernitric acid solution (Center for Atomic and Molecular Technologies, Graduate School of Engineering, Associate Professor Katsuhisa KITANO)
• Diamond bur for suppressing heat generation in bone resection (Graduate School of Engineering, Assistant Professor Urara SATAKE)
• Visualization Technology for Disease States Based on Multidimensional Chemical Distribution Information (Department of Physics, Graduate School of Science, Associate Professor Yoichi OTSUKA)
• Raman spectroscopic tissue detection for minimally-invasive and precise medicine (Department of Applied Physics, Graduate School of Engineering, Assistant Professor Yasuaki KUMAMOTO)
• Construction of the rapid detection system of gut bacterium for health awareness improvement (Life and Medical Photonics Division, Institute for Open and Transdisciplinary Research Initiatives, Specially Appointed Associate Professor Masato SAITO)
• Development of New Techniques for Wireless EEG Measurement Device with Light Weight and Long Time Operation (Division of Electrical, Electronic and Infocommunications Engineering, Graduate School of Engineering, Associate Professor Daisuke KANEMOTO)
• Biocompatible Tough and Flexible Polymeric Materials (Institute for Advanced Co-Creation Studies/Department of Chemistry, Graduate School of Science, Professor Yoshinori TAKASHIMA, Assistant Professor Junsu PARK)
• Development of a Method for Early Diagnosis of Preterm Labor and Abruptio Placentae Using Sheet-Type Wireless Uterine EMG Sensors: Towards Reducing Neonatal Encephalopathy (Department of Obstetrics & Gynecology, Graduate School of Medicine, Professor Tadashi KIMURA)
• Development of an optimized method for metabolomic analysis of human samples (Department of Metabolic Medicine, Graduate School of Medicine, Professor Iichiro SHIMOMURA)
• Development of a system to measure the bone mineral density from x-rays (Department of Orthopaedic Surgery, Graduate School of Medicine, Assistant Professor Keisuke UEMURA)
• Development of an AI system to predict facial morphology after orthodontic treatment (Department of Orthodontics, Osaka University Dental Hospital, Associate Professor (Lecturer) Chihiro TANIKAWA)
• Development of a medical device to visualize abnormalities in the 3D surface morphology of the skull as a color map (Department of Orthodontics, Osaka University Dental Hospital, Associate Professor (Lecturer) Chihiro TANIKAWA)
• Development of“ peptide” pulp capping agent promoting wound healing process of pulp tissue (Osaka University Dental Hospital, Associate Professor (Lecturer) Yusuke TAKAHASHI)
• Development of minimally invasive device system for evaluating the prospect of uterine receptivity for each cycle (Department of Obstetrics & Gynecology, Graduate School of Medicine, Professor Tadashi KIMURA)
• Development of novel treatment method for meniscal injury with defect, using a atelo collagen-based meniscal substitute (Department of Health and Sport Sciences, Medicine for Sports and Performing Arts, Graduate School of Medicine, Professor Ken NAKATA)
• Restoration of Motor and Communication by Wireless Implantable Brain Machine Interfaces (Department of Neurological Diagnosis and Restoration, Graduate School of Medicine, Specially Appointed Professor Masayuki HIRATA)
• Development of a method for objectively monitoring the efficacy of analgesics on postoperative pain (Graduate School of Frontier Biosciences, Guest Professor Aya NAKAE)
• Research and development of innovative remote cardiac rehabilitation system (Department of Cardiovascular Medicine, Graduate School of Medicine, Professor Yasushi SAKATA, Specially Appointed Researcher Tatsunori TANIGUCHI)

Regenerative medicine

• Repair of incurable meniscal injuries using an aligned electrospun nanofibrous scaffold combined with mesenchymal stem cells (Department of Orthopaedic Surgery, Graduate School of Medicine, Visiting Academic Staff Kazunori SHIMOMURA)
• Development of Meniscus Regeneration Therapy Using Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells and Atelocollagen Meniscus Regeneration Material (Department of Health and Sport Sciences, Medicine for Sports and Performing Arts, Graduate School of Medicine, Professor Ken NAKATA)
• Regeneration therapy using autologous bone marrow derived M2 macrophage for severe heart failure. (Osaka University Hospital, Assistant Professor Kizuku YAMASHITA)
• Development of a novel therapy for α-synucleinopathy using regulatory T cells (Department of Neurology, Graduate school of Medicine, Professor Hideki MOCHIZUKI)
• Novel Method Maximizing MSC-Therapies (Department of Metabolic Medicine, Graduate School of Medicine, Professor Iichiro SHIMOMURA)
• Development of new periodontal tissue regeneration therapy using autologous adipose tissue-derived stem cells (Graduate School of Dentistry, Professor Shinya MURAKAMI)

Diagnostics

• Development of a New Method for Detection of Effects Induced by Maternal Immune Activation (Department of Neuroscience and Cell Biology, Graduate School of Medicine, Professor Shoichi SHIMADA)
• Establishment and clinical application of rapid and highly accurate identification method for nontuberculous mycobacteriosis by real-time core genome analysis (Immunology Frontier Research Center, Assistant Professor Kiyoharu FUKUSHIMA)
• Development of a diagnostic method for patients with chronic inflammatory disease using analysis of sugar chains of IgGs (Department of Biopathological Information Science, Graduate School of Medicine, Professor Eiji MIYOSHI)

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